Section: User Commands (1)Updated: November 30, 2004Local indexUp
mssstest - Normalisationo of disease scores - originally developed for the EDSS for Multiple Sclerosis
Suppose one is interested in determining whether the genotype at some locus
of interest affects the rate of progression of disease of people with Multiple
Sclerosis (MS). One method would be to calculate the mean EDSS score in patients
with each of the genotypes and test whether they are significantly different.
However, this approach is inefficient if patients have their EDSS assessed at
different durations of disease, as patients who have had MS longer typically
have higher EDSS scores regardless of their genotype. By adjusting for duration,
a more powerful test can be developed.
MSSStest is a program for implementing the method described in the article
The Multiple Sclerosis Severity Score. R. Roxburgh S. Seaman et al. (2004),
accepted for publication by Neurology. It calculates MSSS scores and uses
these scores to test for differences between disease progression rates in
different groups defined by genotype at some locus.
To use the program first copy the table of disease scores to the current
directory. You are expected to use the EDSS scores provided by the authors.
The program does not accept options, it should, though. The output goes to the files "msss.out"